PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata

The "PepSAVI-MS" Pipeline for Natural Product Bioactive Peptide Discovery.

The recent increase in extensively drug-resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for new antibiotic backbones with novel mechanisms of action. Here, we report the development of the PepSAVI-MS pipeline for bioactive peptide discovery. This highly versatile platform employs mass spectrometry and statistics to identify bio...

Phytochemical and Pharmacological Potential of Viola Odorata

Sweet violet also known as the Viola odorata, blooms in continental climate conditions in early spring with delicate flowers of attractive scent. It has been traditionally the part of various indigenous preparations and being used to cure respiratory and inflammatory conditions. Present review article is an attempt to cover recent developments in phytochemical and pharmacological potential of d...

Diuretic, Laxative and Toxicity Studies of Viola odorata Aerial Parts

Efficacy of Viola odorata in Treatment of Chronic Insomnia

BACKGROUND Insomnia is the most common sleep disorder that reduces quality of life. OBJECTIVES Due to side effects of hypnotic drug and the increasing demand for alternative medicine substitutes, violet oil (VO) was used in this study. VO is a known medication in Iranian traditional medicine that induces sleep in insomniac patients. PATIENTS AND METHODS This study was conducted as an experi...

Biological Activity of Viola Odorata Linn against Mycobacterium Tuberculosis

In the present study the antibacterial activity of extracts and pure constituents of V. odorata was evaluated against Mycobacterium tuberculosis H37Rv and clinical isolate of MDR-TB (M. avium, ATCC 25291). Crude ethanol extract of the plant was fractionated with different solvents to yield respective extracts. The n-hexane and Dichloromethane fractions showing good activity against both strains...